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Research on Fibromyalgia
Plasma levels on nociceptin in female fibromyalgia syndrome
patients.
| AUTHORS:
| Anderberg UM; Liu Z; Berglund L;
Nyberg F
| AUTHOR AFFILIATION:
| Department of Neuroscience
Psychiatry, University Hospital, Uppsala, Sweden.
| SOURCE:
| Z Rheumatol 1998;57 Suppl 2:77-80
| CITATION IDS:
| PMID: 10025089 UI: 99149228
| ABSTRACT:
| Fibromyalgia syndrome (FMS) is a
frequent pain disorder in women. The pathophysiologic mechanism behind
this disorder is still unexplained; however, alterations in both
monoamines, neuropeptides and in the stress axis have been found. This
study was designed to determine the levels of the newly discovered
neuropeptide nociceptin in hormonally different FMS patients and
corresponding controls. The results showed that the nociceptin
concentrations of the patients were lower than in controls. It also showed
decreased levels with significant differences between the cyclic patients
in the luteal phase of the menstrual cycle, compared to the corresponding
controls. Our results suggest that the perturbed nociceptin concentrations
of the FMS patients may be linked to both the sex hormones and to the
stress system and that these changes might be one of several possible
pathophysiologic mechanisms involved in the FMS.
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