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Research on Fibromyalgia
Hormonal pertubations in fibromyalgia syndrome.
| AUTHORS:
| Neeck G; Riedel W
| AUTHOR AFFILIATION:
| Department of Rheumatology,
University of Giessen, Bad Nauheim, Germany.
| SOURCE:
| Ann N Y Acad Sci 1999 Jun
22;876:325-38; discussion 339
| CITATION IDS:
| PMID: 10415628 UI: 99344117
| ABSTRACT:
| The symptomatology characterizing
fibromyalgia (FM) comprises three systems: the musculoskeletal system with
widespread muscular pain, neuroendocrine disorders, and psychological
distress including depression. Though the most prominent symptom of FM is
pain in defined points of the musculoskeletal system, the numerous other
somatoform and psychological disorders suppose a common primary
disturbance which we consider to originate within higher levels of the
central nervous system. Recent studies of the entire endocrine profile of
FM patients following a simultaneous challenge of the hypophysis with
corticotropin- releasing hormone (CRH), thyrotropin-releasing hormone,
growth hormone- releasing hormone, and luteinizing hormone-releasing
hormone support the hypothesis that an elevated activity of CRH neurons
determines not only many symptoms of FM but may also cause the deviations
observed in the other hormonal axes. Hypothalamic CRH neurons thus may
play a key role not only in "resetting" the various endocrine
loops but possibly also nociceptive and psychological mechanisms as well.
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