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Research on Fibromyalgia
Disordered growth hormone secretion in fibromyalgia: a
review of recent findings and a hypothesized etiology.
| AUTHORS:
| Bennett RM
| AUTHOR AFFILIATION:
| Dept. Medicine (L329A), Oregon
Health Sciences University, Portland 97201, USA.
| SOURCE:
| Z Rheumatol 1998;57 Suppl 2:72-6
| CITATION IDS:
| PMID: 10025088 UI: 99149227
| ABSTRACT:
| Growth hormone (GH) deficiency
occurs in about 30% of fibromyalgia patients. Treatment of GH deficient
fibromyalgia patients with recombinant growth hormone improves several
clinical features, including the tender point count. Defective GH
secretion in these patients appears to be due to increased somatostatin
tone in the hypothalamus. An hypothesis is presented which relates
dysfunctional GH secretion to the effects of intermittent
hypercortisolemia on upregulating the density of beta-adrenergic receptors
in the hypothalamus. The resulting augmentation of beta-adrenergic tone
stimulates the release of somatostatin, thus, impairing GH secretion.
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