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Research on Fibromyalgia
Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a
90-day open study.
| AUTHORS:
| Puttini PS; Caruso I
| AUTHOR AFFILIATION:
| Rheumatology Unit, L Sacco
Hospital, Milan, Italy.
| SOURCE:
| J Int Med Res 1992 Apr;20(2):182-9
| CITATION IDS:
| PMID: 1521674 UI: 92394366
| ABSTRACT:
| The efficacy and tolerability of
5-hydroxy-L-tryptophan (5-HTP) were studied in an open 90-day study in 50
patients affected by primary fibromyalgia syndrome. When all the clinical
variables studied throughout the trial (number of tender points, anxiety,
pain intensity, quality of sleep, fatigue) were compared with baseline
results, they all showed a significant improvement (P less than 0.001).
The overall evaluation of the patient condition assessed by the patient
and the investigator indicated a 'good' or 'fair' clinical improvement in
nearly 50% of the patients during the treatment period. A total of 15
(30%) patients reported side-effects but only one patient was withdrawn
from the treatment for this reason. No abnormality in the laboratory
evaluation was observed. It is concluded that 5-HTP is effective in
improving the symptoms of primary fibromyalgia syndrome and that it
maintains its efficacy throughout the 90-day period of treatment
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